![]() ![]() TBC-domain family members are strongly conserved with high levels of homology 13. The TBC (Tre-2/Bub2/Cdc16, TBC) structural domain is a conserved amino acid sequence consisting of the oncogene Tre-2 (gene symbol: USP6) and the structural domains of the yeast cell circulation regulator genes Bub2 and Cdc16 12. Therefore, the identification of novel markers and targets for treating CRC is necessary for improving the disease prognosis. The number of molecularly stratified treatment options is increasing, as is the use of biomarkers to guide prediction and treatment decisions 11. Molecular-targeted therapy for CRC has become a hot topic 9, 10. Treatment methods for CRC include chemotherapy, surgery, radiotherapy, and molecular-targeted therapy 7, 8. Statistics show that the tumor frequently recurs and metastasizes, spreading especially to the liver, lung, bone, ovaries, peritoneal and the five-year survival rate for such patients is approximately 10% 5, 6. Its pathogenesis appears to involve multiple factors and steps 2, including genetics, diet, and lifestyle habits 3, 4. Colorectal cancer (CRC) is a tumor of the gastrointestinal system, ranking third in incidence among malignancies and second in lethality among cancers 1.
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